Understanding how immune cells affect brain development and disorders in children
Neuroimmunological insights into brain development and dysfunction: an integrative approach focused on microglial dynamics
['FUNDING_OTHER'] · COLD SPRING HARBOR LABORATORY · NIH-10472831
This study is looking at how certain immune cells in the brain affect the development and challenges of children with conditions like autism and intellectual disabilities, hoping to find new ways to help them feel better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLD SPRING HARBOR LABORATORY (nih funded) |
| Locations | 1 site (COLD SPRING HARBOR, UNITED STATES) |
| Trial ID | NIH-10472831 on ClinicalTrials.gov |
What this research studies
This research investigates the role of immune cells in the brain, specifically focusing on microglia, and how they influence brain development and dysfunction in children. By examining the interplay between genetics and environmental factors, the study aims to uncover the underlying causes of neurodevelopmental disorders such as autism and intellectual disability. The approach combines clinical observations with experimental models to identify how immune responses may contribute to these conditions. This could lead to new insights into potential therapeutic targets for improving outcomes in affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-21 who are diagnosed with neurodevelopmental disorders such as autism or intellectual disability.
Not a fit: Patients with neurodevelopmental disorders that are solely genetic in origin and do not involve immune system interactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurodevelopmental disorders, improving the quality of life for affected children and their families.
How similar studies have performed: Other research has shown promising results in understanding the role of immune cells in brain disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
COLD SPRING HARBOR, UNITED STATES
- COLD SPRING HARBOR LABORATORY — COLD SPRING HARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEADLE, LUCAS M — COLD SPRING HARBOR LABORATORY
- Study coordinator: CHEADLE, LUCAS M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.