Understanding how immune cells affect bone healing in gum disease
Official title: Osteoimmunology of Retarded Bone Regeneration in Periodontitis
Funded at Nova Southeastern University · NIH-10855762 · Data updated 2026-11-12
This study is looking into why people with gum disease, called periodontitis, have trouble healing their bones after treatment, and it hopes to find new ways to help improve healing for those patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nova Southeastern University NIH-funded |
| Lab location | 1 site (Fort Lauderdale-Davie, UNITED STATES) |
| Project start | August 1, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $353,780 |
| NIH project number | 5R01DE029709-05 |
| Project ID | NIH-10855762 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who have been diagnosed with periodontitis.
✕Less likely to help
Patients with conditions unrelated to periodontitis or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the reasons behind slow bone healing in patients with periodontitis, a serious gum disease. It focuses on specific proteins that may disrupt the natural process of bone regeneration after treatment. By examining the interactions between immune cells and bone-forming cells, the study aims to uncover the molecular mechanisms that lead to impaired healing. Patients with periodontitis may benefit from insights gained through this research, potentially leading to improved treatment options.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance bone regeneration in patients with periodontitis.
How similar studies have gone: Previous research has shown promising results in understanding the immune system's role in bone regeneration, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Nova Southeastern University
Fort Lauderdale-Davie, United States Active
Researchers
- Principal investigator: Kawai, Toshihisa — Nova Southeastern University
- Study coordinator: Kawai, Toshihisa
Related research
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Diabetes-Driven Changes in Dendritic Cells and T Cells in Gum Disease
This project studies how poorly controlled diabetes alters immune cells in periodontitis to worsen gum disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.