Understanding how immune cells affect blood vessel growth in retinopathy
The Mechanism of Immune-Vascular Crosstalk in Retinopathy
['FUNDING_R01'] · BOSTON CHILDREN'S HOSPITAL · NIH-10610869
This study is looking at how immune cells and blood vessels work together in premature babies to understand retinopathy of prematurity (ROP), a condition that can cause vision problems, with the goal of finding new ways to help prevent or treat it.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10610869 on ClinicalTrials.gov |
What this research studies
This research investigates the complex interactions between immune cells and blood vessels in the development of retinopathy of prematurity (ROP), a condition that can lead to blindness in premature infants. The study aims to uncover the molecular mechanisms that drive ROP, focusing on how immune responses and inflammation contribute to abnormal blood vessel growth in the retina. By examining the role of specific immune cells, particularly myeloid cells, the research seeks to identify potential new therapeutic strategies to prevent or treat ROP. The findings could lead to earlier interventions that could protect the vision of at-risk infants.
Who could benefit from this research
Good fit: Ideal candidates for this research are premature infants who are at high risk for developing retinopathy of prematurity.
Not a fit: Patients who are not premature or do not have a diagnosis of retinopathy of prematurity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new preventative therapies for retinopathy of prematurity, potentially reducing the incidence of blindness in affected infants.
How similar studies have performed: There is increasing evidence supporting the role of immune cells in vascular development, suggesting that this approach may yield significant insights, although it is still an emerging area of research.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUN, YE — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: SUN, YE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.