Understanding how immune cells affect back and leg pain from disc herniation
Deciphering Macrophage Phenotype and Function in Disc Herniation and associated Back/leg Pain
This study is looking at how certain immune cells called macrophages might be involved in causing back and leg pain from herniated discs, with the hope of finding new ways to help relieve that pain for people who are suffering.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10805485 on NIH RePORTER |
What this research studies
This research investigates the role of macrophages, a type of immune cell, in the development of back and leg pain caused by intervertebral disc herniation. By examining how these cells behave and change in response to their environment, the study aims to uncover the mechanisms behind inflammation and pain associated with disc issues. The researchers will analyze different macrophage populations at various stages of disc herniation to determine their specific contributions to pain and inflammation. This could lead to new therapeutic strategies that target these immune cells to alleviate pain and improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing back and leg pain due to intervertebral disc herniation.
Not a fit: Patients with back pain not related to disc herniation or those with other unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that reduce back and leg pain for patients suffering from disc herniation.
How similar studies have performed: Other research has shown promising results in understanding the role of immune cells in pain mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Li, Xudong J. — University of Virginia
- Study coordinator: Li, Xudong J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.