Understanding how immune cells affect ALS progression
The Role of Neutrophil Heterogeneity and Molecular Mechanisms in Driving ALS
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10997602
This study is looking at how a type of immune cell called neutrophils might affect the progression of ALS by examining blood samples from patients, with the hope of finding new ways to help manage the disease.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10997602 on ClinicalTrials.gov |
What this research studies
This research investigates the role of neutrophils, a type of immune cell, in the progression of amyotrophic lateral sclerosis (ALS). It aims to understand how these cells respond to neuronal damage and whether they contribute to the worsening of the disease. By analyzing blood samples from ALS patients, the study will explore the relationship between neutrophil levels and disease progression, potentially identifying new therapeutic targets. The research combines laboratory analysis with predictive modeling to assess the impact of neutrophils on motor neuron health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with amyotrophic lateral sclerosis (ALS).
Not a fit: Patients with other neurological conditions unrelated to ALS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or alter the progression of ALS.
How similar studies have performed: Previous studies have shown that immune responses play a significant role in ALS, suggesting that this research could build on established findings.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BAIRD, LILLIA — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: BAIRD, LILLIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's disease patient