Understanding how immune cells affect ALS progression
Official title: The Role of Neutrophil Heterogeneity and Molecular Mechanisms in Driving ALS
Funded at University of Michigan at Ann Arbor · NIH-10997602 · Data updated 2026-11-12
This study is looking at how a type of immune cell called neutrophils might affect the progression of ALS by examining blood samples from patients, with the hope of finding new ways to help manage the disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $43,051 |
| NIH project number | 1F31NS139629-01 |
| Project ID | NIH-10997602 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with amyotrophic lateral sclerosis (ALS).
✕Less likely to help
Patients with other neurological conditions unrelated to ALS may not benefit from this research.
What this research studies
This research investigates the role of neutrophils, a type of immune cell, in the progression of amyotrophic lateral sclerosis (ALS). It aims to understand how these cells respond to neuronal damage and whether they contribute to the worsening of the disease. By analyzing blood samples from ALS patients, the study will explore the relationship between neutrophil levels and disease progression, potentially identifying new therapeutic targets. The research combines laboratory analysis with predictive modeling to assess the impact of neutrophils on motor neuron health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or alter the progression of ALS.
How similar studies have gone: Previous studies have shown that immune responses play a significant role in ALS, suggesting that this research could build on established findings.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Baird, Lillia — University of Michigan at Ann Arbor
- Study coordinator: Baird, Lillia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.