Understanding how immune cells adapt to infections
The IRF regulatory network in innate immune training of macrophages
This study is looking at how certain immune cells called macrophages learn from past infections to better fight off future ones, which could help develop new ways to boost the immune system for people who need it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11133932 on NIH RePORTER |
What this research studies
This research investigates how macrophages, key immune cells, adapt their responses to infections based on their previous encounters with pathogens. By examining the changes in the macrophage's genetic material, the study aims to uncover the mechanisms behind 'innate immune training,' which enhances the cells' ability to fight off future infections. The researchers will focus on specific proteins that regulate these changes and how they work together to influence immune responses. This could lead to new strategies for improving immune function in patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that compromise their immune system or those at high risk for infections.
Not a fit: Patients with stable immune function and no history of recurrent infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for infections by enhancing the immune response in patients.
How similar studies have performed: Previous research has shown promising results in understanding immune cell training, indicating that this approach has potential for significant advancements.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Hoffmann, Alexander — University of California Los Angeles
- Study coordinator: Hoffmann, Alexander
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.