Understanding how immune cells adapt in tissues to fight infections and prevent autoimmunity
Interrogating unique DC adaptations to tissue to promote barrier immunity and tolerance
This study is looking at how special immune cells called dendritic cells work in different parts of the body, like the skin and lungs, to help fight off infections while keeping us safe from harm, with the goal of finding better ways to improve vaccines and treat illnesses like cancer and viral infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11012784 on NIH RePORTER |
What this research studies
This research investigates how dendritic cells (DCs), which are crucial for immune responses, adapt in different tissues like the skin, lungs, and gut to effectively detect pathogens while preventing damage to the body. The study aims to uncover the mechanisms that allow these cells to balance their roles in immunity and self-tolerance. By exploring how DCs differentiate and function in various environments, the research seeks to improve strategies for vaccination and treatment of viral infections and cancer. Patients may benefit from insights gained about enhancing immune responses through better-targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions that affect immune responses, such as cancer patients or those with viral infections.
Not a fit: Patients with stable, non-immune related conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved immunization strategies and therapies for viral infections and cancer.
How similar studies have performed: Previous research has shown promise in understanding immune cell adaptations, indicating potential for success in this novel approach.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Anandasabapathy, Niroshana — Weill Medical Coll of Cornell Univ
- Study coordinator: Anandasabapathy, Niroshana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.