Understanding how immune cells adapt and respond to different conditions
Plasticity of Innate Lymphoid Cells: Mechanisms and Biological Impact
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-10597244
This study is looking at how certain immune cells, called innate lymphoid cells, can change their roles in response to different situations, especially in conditions like asthma and cancer, to find new ways to improve treatments for these diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10597244 on ClinicalTrials.gov |
What this research studies
This research investigates the flexibility of innate lymphoid cells (ILCs), which are crucial components of the immune system that help regulate responses to various stimuli. The study aims to explore how these cells can change their functions in response to different environments, particularly in the context of diseases like asthma and cancer. By examining the mechanisms behind this plasticity, researchers hope to uncover new ways to manipulate immune responses for therapeutic benefits. The research involves both laboratory experiments and in vivo studies to assess the behavior of ILCs in human tissues and disease models.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with asthma, autoimmune conditions, or cancers who are interested in novel immunotherapy approaches.
Not a fit: Patients with stable, non-immune related conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance immune responses against diseases such as asthma and cancer.
How similar studies have performed: Previous research has shown promising results in understanding immune cell plasticity, indicating that this approach has potential for significant advancements in treatment.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COLONNA, MARCO — WASHINGTON UNIVERSITY
- Study coordinator: COLONNA, MARCO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer