Understanding how immune cell receptors change during immune activation
Composition and structure of antibody receptors at the surface of primary human cells during immune activation
['FUNDING_U01'] · UNIVERSITY OF GEORGIA · NIH-10842256
This study is looking at how certain immune cell receptors change when they are activated, especially during stress or illness, to better understand how they work with antibodies and how we might improve immune responses, which could help in treating conditions like sickle cell disease.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF GEORGIA (nih funded) |
| Locations | 1 site (ATHENS, UNITED STATES) |
| Trial ID | NIH-10842256 on ClinicalTrials.gov |
What this research studies
This research investigates the composition and structure of antibody receptors on human immune cells when they are activated. It focuses on how these receptors, known as Fc gamma receptors, interact with antibodies and how their modifications can affect immune responses. By examining the changes in these receptors during stress and disease, the research aims to uncover important details about their function and how they can be influenced to improve immune responses. This could lead to new insights into treating conditions like sickle cell disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with sickle cell disease or related conditions who are interested in understanding their immune system better.
Not a fit: Patients without sickle cell disease or those not experiencing immune activation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune responses, potentially leading to better treatments for diseases like sickle cell disease.
How similar studies have performed: Other research has shown promising results in understanding immune receptor modifications, suggesting that this approach could yield valuable insights.
Where this research is happening
ATHENS, UNITED STATES
- UNIVERSITY OF GEORGIA — ATHENS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BARB, ADAM WESLEY — UNIVERSITY OF GEORGIA
- Study coordinator: BARB, ADAM WESLEY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Hb SS disease, HbSS disease, Hemoglobin S Disease, Hemoglobin sickle cell disease, Hemoglobin sickle cell disorder