Understanding how immune cell precursors move from bone marrow to tissues
Official title: Mobilization and trafficking of central ILC progenitors
Funded at University of Michigan at Ann Arbor · NIH-11010843 · Data updated 2026-11-12
This study looks at how certain immune cells, called ILC progenitors, move from the bone marrow to different parts of the body, especially when there’s inflammation, to help us understand how our immune system works and find new ways to treat allergies and other immune-related issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | August 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $446,624 |
| NIH project number | 5R01AI173179-03 |
| Project ID | NIH-11010843 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with immune system disorders, particularly those related to allergies or inflammation.
✕Less likely to help
Patients with stable immune conditions or those not experiencing allergic responses may not benefit from this research.
What this research studies
This research investigates the movement and distribution of innate lymphoid cell (ILC) progenitors, which are crucial for maintaining immune function and tissue health. The study focuses on how these progenitors are mobilized from the bone marrow and how they migrate to various tissues in the body, especially during inflammatory conditions. By exploring the mechanisms that regulate this process, the research aims to uncover important insights into immune responses and potential therapeutic targets for allergies and other immune-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses and treating allergic conditions.
How similar studies have gone: Previous research has shown promising results in understanding immune cell dynamics, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Kim, Chang H — University of Michigan at Ann Arbor
- Study coordinator: Kim, Chang H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.