Understanding how immune cell exosomes contribute to COPD
Pathogenic Exosomes in COPD
['FUNDING_OTHER'] · UNIVERSITY OF ALABAMA AT BIRMINGHAM · NIH-11063115
This study is looking at tiny particles from immune cells to see how they might affect the progression of COPD, using mice to help us understand how these particles could lead to tissue damage and possibly help us find better treatments for people with COPD.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ALABAMA AT BIRMINGHAM (nih funded) |
| Locations | 1 site (BIRMINGHAM, UNITED STATES) |
| Trial ID | NIH-11063115 on ClinicalTrials.gov |
What this research studies
This research investigates the role of immune cell-derived exosomes in chronic obstructive pulmonary disease (COPD) using a mouse model. By studying how these exosomes transfer disease characteristics from humans to mice, the research aims to uncover new mechanisms of disease progression and potential therapeutic targets. The approach includes examining how exosomes can enhance protease activity and lead to tissue damage, providing insights that could improve treatment strategies for COPD patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with COPD, particularly those with alpha-1 antitrypsin deficiency.
Not a fit: Patients with COPD who do not have alpha-1 antitrypsin deficiency or those with other unrelated respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that better manage or even prevent COPD.
How similar studies have performed: Other research has shown promise in understanding the role of exosomes in various diseases, suggesting that this approach could yield valuable insights for COPD as well.
Where this research is happening
BIRMINGHAM, UNITED STATES
- UNIVERSITY OF ALABAMA AT BIRMINGHAM — BIRMINGHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BLALOCK, J EDWIN — UNIVERSITY OF ALABAMA AT BIRMINGHAM
- Study coordinator: BLALOCK, J EDWIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.