Understanding how immune and mechanical factors affect aortic disease
Modeling Multiscale Immuno-Mechanics in Aortic Disease
This study is looking at how the immune system and the strength of blood vessels work together to affect high blood pressure in kids and teens, using computer models and mouse research to find new ways to help treat aortic diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11001207 on NIH RePORTER |
What this research studies
This research investigates the interplay between immune responses and mechanical properties in the development of aortic diseases, particularly focusing on how these factors contribute to hypertension in children and adolescents. By using advanced computational models, the study aims to analyze data from mouse models to understand how age, sex, and immune status influence aortic health. The goal is to gather extensive data that can help reveal new insights into the mechanisms behind aortic disease and improve treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and adolescents experiencing early onset hypertension or related aortic conditions.
Not a fit: Patients with established aortic diseases unrelated to hypertension or those outside the pediatric age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of aortic diseases in young patients, potentially reducing the incidence of hypertension-related complications.
How similar studies have performed: Previous research has shown promise in understanding the relationship between immune responses and vascular diseases, indicating that this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Humphrey, Jay D. — Yale University
- Study coordinator: Humphrey, Jay D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.