Understanding how immune and epithelial cells interact during acute pancreatitis
Epithelial-immune cell crosstalk during injury and recovery in acute pancreatitis
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10979149
This study is looking at how immune cells and pancreatic cells work together during acute pancreatitis to help the tissue heal, focusing on a special protein called interleukin-22, and it’s aimed at finding better ways to treat this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10979149 on ClinicalTrials.gov |
What this research studies
This research investigates the interactions between immune cells and epithelial cells in the pancreas during acute pancreatitis, a serious inflammatory condition. It aims to understand how these cells communicate and how this communication affects tissue repair and recovery. The study will explore the role of specific cytokines, particularly interleukin-22, in protecting pancreatic tissue and promoting healing. By using animal models, researchers will examine the effects of these interactions on the severity of the disease and potential therapeutic approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with acute pancreatitis, particularly those experiencing severe symptoms.
Not a fit: Patients with chronic pancreatitis or those who do not have an active episode of acute pancreatitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance recovery from acute pancreatitis and reduce the risk of severe complications.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in gastrointestinal conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FRANKEL, TIMOTHY LOUIS — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: FRANKEL, TIMOTHY LOUIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.