Understanding how immune activation affects brain function in women with HIV
Evaluation of Neurobiological Mechanisms Mediating the Effect of Immune Activation on Neurocognitive Impairment and the Role of Psychosocial Factors Among Women Living with HIV
['FUNDING_R01'] · UNIVERSITY OF ALABAMA AT BIRMINGHAM · NIH-10904696
This study is looking at how ongoing immune system activity in women with HIV, even when the virus is under control, might affect their thinking and memory skills, and it aims to find out what factors could be influencing these challenges.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ALABAMA AT BIRMINGHAM (nih funded) |
| Locations | 1 site (BIRMINGHAM, UNITED STATES) |
| Trial ID | NIH-10904696 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between immune activation and cognitive impairment in women living with HIV. It focuses on how chronic immune activation, even when the virus is suppressed, can lead to cognitive challenges. The study will utilize existing data and biological samples from the Women's Interagency HIV Study to explore neurobiological pathways and psychosocial factors that may contribute to these cognitive issues. By examining these connections, the research aims to identify specific risk factors and mechanisms that affect brain function in this population.
Who could benefit from this research
Good fit: Ideal candidates for this research are women living with HIV who experience cognitive impairment or are at risk for it.
Not a fit: Patients who are not living with HIV or who do not experience cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of cognitive impairment in women living with HIV.
How similar studies have performed: Previous research has shown that immune activation can impact cognitive function, suggesting that this approach may yield valuable insights.
Where this research is happening
BIRMINGHAM, UNITED STATES
- UNIVERSITY OF ALABAMA AT BIRMINGHAM — BIRMINGHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WHEELER, PARIYA FAZELI — UNIVERSITY OF ALABAMA AT BIRMINGHAM
- Study coordinator: WHEELER, PARIYA FAZELI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus