Understanding how ILC2 immune cells affect allergic asthma in adults
Official title: The responsiveness of ILC2s in allergic airway inflammation
Funded at University of New Mexico Health Scis Ctr · NIH-11400523 · Data updated 2026-11-12
This grant studies how a specific immune group, ILC2s, influence allergic asthma in adults and whether turning down their activity could help treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico Health Scis Ctr NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project start | September 1, 2025 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $488,031 |
| NIH project number | 5R01HL175382-02 |
| Project ID | NIH-11400523 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with allergic asthma or related airway inflammation who consent to participate in future translational studies.
✕Less likely to help
People without allergic asthma or those who do not respond to immune-modulating strategies may not benefit.
What this research studies
If funded, researchers will explore how ILC2 cells contribute to allergic airway inflammation in adults and identify ways to dampen their activity. The project builds on prior work showing CIS/CISH may regulate TH2 responses and airway inflammation, aiming to uncover mechanisms that could reduce asthma symptoms. The findings could point toward new therapeutic strategies that lessen airway inflammation and improve lung function for people with allergic asthma.
Why it matters
Potential benefit: If successful, the work could lead to new approaches that lessen asthma symptoms and reduce airway inflammation in adults.
How similar studies have gone: Previous studies suggest regulatory pathways can control TH2/ILC2-driven inflammation, but targeted human applications remain under investigation.
Where this research is happening
-
University of New Mexico Health Scis Ctr
Albuquerque, United States Active
Researchers
- Principal investigator: Yang, Xuexian — University of New Mexico Health Scis Ctr
- Study coordinator: Yang, Xuexian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.