Understanding how IL-17 helps protect kidneys during fungal infections
Official title: IL-17-epithelial cells interaction in organ damaging infections
Funded at State University New York Stony Brook · NIH-11129643 · Data updated 2026-11-12
This study is looking at how a molecule called IL-17 helps protect kidney cells from damage caused by a fungus that can lead to serious infections, with the goal of finding better treatments for people dealing with these tough infections.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | July 2, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $199,375 |
| NIH project number | 5R21AI181831-02 |
| Project ID | NIH-11129643 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with severe bloodstream infections caused by Candida albicans, particularly those experiencing kidney complications.
✕Less likely to help
Patients with fungal infections that do not involve kidney damage or those who are not infected with Candida albicans may not benefit from this research.
What this research studies
This research investigates the role of the immune molecule IL-17 in protecting kidney cells from damage caused by the fungus Candida albicans, which can lead to severe bloodstream infections. The study focuses on how IL-17 influences kidney cell behavior during infection, particularly looking at cell death and the mechanisms that protect against it. By examining the interactions between IL-17 and kidney cells, researchers aim to uncover new insights that could improve treatment strategies for patients suffering from serious fungal infections.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that enhance kidney protection during fungal infections, potentially reducing mortality rates.
How similar studies have gone: Previous research has shown promising results in understanding immune responses to fungal infections, suggesting that this approach may yield valuable insights.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Biswas, Partha Sarathi — State University New York Stony Brook
- Study coordinator: Biswas, Partha Sarathi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.