Understanding how IL-17 helps protect kidneys during fungal infections
IL-17-epithelial cells interaction in organ damaging infections
['FUNDING_R21'] · STATE UNIVERSITY NEW YORK STONY BROOK · NIH-11129643
This study is looking at how a molecule called IL-17 helps protect kidney cells from damage caused by a fungus that can lead to serious infections, with the goal of finding better treatments for people dealing with these tough infections.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY NEW YORK STONY BROOK (nih funded) |
| Locations | 1 site (STONY BROOK, UNITED STATES) |
| Trial ID | NIH-11129643 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the immune molecule IL-17 in protecting kidney cells from damage caused by the fungus Candida albicans, which can lead to severe bloodstream infections. The study focuses on how IL-17 influences kidney cell behavior during infection, particularly looking at cell death and the mechanisms that protect against it. By examining the interactions between IL-17 and kidney cells, researchers aim to uncover new insights that could improve treatment strategies for patients suffering from serious fungal infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with severe bloodstream infections caused by Candida albicans, particularly those experiencing kidney complications.
Not a fit: Patients with fungal infections that do not involve kidney damage or those who are not infected with Candida albicans may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that enhance kidney protection during fungal infections, potentially reducing mortality rates.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to fungal infections, suggesting that this approach may yield valuable insights.
Where this research is happening
STONY BROOK, UNITED STATES
- STATE UNIVERSITY NEW YORK STONY BROOK — STONY BROOK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BISWAS, PARTHA SARATHI — STATE UNIVERSITY NEW YORK STONY BROOK
- Study coordinator: BISWAS, PARTHA SARATHI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autoinflammatory diseases, autoinflammatory disorders