Understanding how IL-17 affects pancreatic cancer development
Dissecting the source and mechanisms of IL-17-mediated modulation of pancreatic tumorigenesis
This study is looking at how a specific immune cell called IL-17 might help pancreatic cancer grow and make it harder to treat, with the hope of finding new ways to fight the disease.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10873838 on NIH RePORTER |
What this research studies
This research investigates the role of IL-17, a type of immune cell, in the development of pancreatic cancer. It aims to identify the mechanisms by which IL-17 contributes to an immunosuppressive environment that hinders effective treatment. The study will utilize genetically engineered mouse models and CRISPR technology to explore how targeting IL-17 can potentially reverse this suppressive environment. By understanding these processes, the research seeks to develop new therapeutic strategies for pancreatic cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pancreatic adenocarcinoma or those at high risk for developing this type of cancer.
Not a fit: Patients with other types of cancer or those without pancreatic cancer risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve outcomes for patients with pancreatic cancer.
How similar studies have performed: Previous research has shown promising results in targeting immune mechanisms in cancer treatment, suggesting potential success for this approach.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Mcallister, Florencia — University of Tx Md Anderson Can Ctr
- Study coordinator: Mcallister, Florencia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.