Understanding how IGSF10 signaling works in the body
Official title: The role of the receptor complex and the cofactors in IGSF10 signaling
Funded at University of Texas Hlth Science Center · NIH-11103210 · Data updated 2026-11-12
This study is looking at a protein called IGSF10 to understand how it works in the body and how it might be linked to issues like delayed puberty and certain cancers, so that patients can gain better insights into these conditions and how they develop.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | June 7, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $354,563 |
| NIH project number | 5U01CA283414-03 |
| Project ID | NIH-11103210 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with hereditary delayed puberty, aggressive breast or lung cancers, or cleidocranial dysplasia.
✕Less likely to help
Patients without any known genetic mutations or conditions related to IGSF10 may not receive direct benefits from this research.
What this research studies
This research investigates the role of IGSF10, a protein involved in various biological processes, including its connection to conditions like delayed puberty and aggressive cancers. The team aims to uncover how IGSF10 interacts with its receptor and cofactors to regulate signaling pathways in cells. By studying these mechanisms, the research hopes to provide insights into the physiological roles of IGSF10 and its implications in diseases. Patients may benefit from a better understanding of how IGSF10-related conditions develop and progress.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the treatment and management of conditions associated with IGSF10 dysregulation, such as certain cancers and hormonal disorders.
How similar studies have gone: While the specific mechanisms of IGSF10 signaling are not well-studied, similar research approaches have successfully uncovered important signaling pathways in other biological contexts.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Shiio, Yuzuru — University of Texas Hlth Science Center
- Study coordinator: Shiio, Yuzuru
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.