Understanding how IGF-1R affects thyroid eye disease
Official title: Regulation of IGF-1R in acute and chronic thyroid eye disease
Funded at University of California, San Diego · NIH-10996866 · Data updated 2026-11-12
This study is looking at how a specific protein called IGF-1R behaves in people with thyroid eye disease, which can affect vision and daily life, to help find new ways to treat the condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $76,756 |
| NIH project number | 1F32EY036715-01 |
| Project ID | NIH-10996866 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with thyroid eye disease, particularly those experiencing acute or chronic symptoms.
✕Less likely to help
Patients with thyroid eye disease who are not undergoing active treatment or those with other unrelated ocular conditions may not benefit from this research.
What this research studies
This research investigates the role of the insulin-like growth factor 1 receptor (IGF-1R) in thyroid eye disease (TED), a condition that can severely impact vision and quality of life. By analyzing tissue samples from patients, the study aims to understand how IGF-1R is expressed and regulated during the acute and chronic phases of TED. The researchers will utilize advanced techniques like single nuclei multiome sequencing and spatial transcriptomics to explore the cellular landscape and interactions in affected tissues. This could lead to insights into the molecular mechanisms driving TED and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate the symptoms of thyroid eye disease and improve patients' quality of life.
How similar studies have gone: Previous research has shown that targeting IGF-1R can be beneficial in other conditions, suggesting potential for success in this area as well.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Cheng, Sarah — University of California, San Diego
- Study coordinator: Cheng, Sarah
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.