Understanding how IGF-1R affects thyroid eye disease
Regulation of IGF-1R in acute and chronic thyroid eye disease
This study is looking at how a specific protein called IGF-1R behaves in people with thyroid eye disease, which can affect vision and daily life, to help find new ways to treat the condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10996866 on NIH RePORTER |
What this research studies
This research investigates the role of the insulin-like growth factor 1 receptor (IGF-1R) in thyroid eye disease (TED), a condition that can severely impact vision and quality of life. By analyzing tissue samples from patients, the study aims to understand how IGF-1R is expressed and regulated during the acute and chronic phases of TED. The researchers will utilize advanced techniques like single nuclei multiome sequencing and spatial transcriptomics to explore the cellular landscape and interactions in affected tissues. This could lead to insights into the molecular mechanisms driving TED and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with thyroid eye disease, particularly those experiencing acute or chronic symptoms.
Not a fit: Patients with thyroid eye disease who are not undergoing active treatment or those with other unrelated ocular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate the symptoms of thyroid eye disease and improve patients' quality of life.
How similar studies have performed: Previous research has shown that targeting IGF-1R can be beneficial in other conditions, suggesting potential for success in this area as well.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Cheng, Sarah — University of California, San Diego
- Study coordinator: Cheng, Sarah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.