Understanding how IgE affects allergic reactions like anaphylaxis
Official title: Non-Templated Regulation of IgE Mediated Anaphylaxis
Funded at Massachusetts General Hospital · NIH-10988320 · Data updated 2026-11-12
This study is looking into why some people with certain allergy antibodies have really bad allergic reactions, like anaphylaxis, while others don’t, and it hopes to find new ways to help those with allergies feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | November 16, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $805,824 |
| NIH project number | 5R01AI179741-02 |
| Project ID | NIH-10988320 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with known allergies, particularly those who have experienced anaphylactic reactions to allergens like peanuts.
✕Less likely to help
Patients who do not have allergies or those who are not at risk for anaphylaxis may not benefit from this research.
What this research studies
This research investigates why some individuals with specific IgE antibodies experience severe allergic reactions, such as anaphylaxis, while others do not. It explores various factors, including the structure of IgE antibodies and their glycosylation patterns, which may influence the severity of allergic responses. By studying these differences, the research aims to identify new therapeutic targets and biomarkers for allergic diseases. The approach includes both human and animal models to assess the impact of IgE modifications on allergic reactions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments and preventive strategies for individuals at risk of severe allergic reactions.
How similar studies have gone: Other research has shown promising results in understanding the role of IgE and its modifications in allergic responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Anthony, Robert Mccullough — Massachusetts General Hospital
- Study coordinator: Anthony, Robert Mccullough
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.