Understanding how hypertension and exercise affect aortic health
Official title: Integrative Mechanobiological Understanding of Effects of Hypertension and Exercise on Thoracic Aortopathy
Funded at Yale University · NIH-11015434 · Data updated 2026-11-12
This study is looking at how high blood pressure and exercise affect the health of the aorta in people with aortic problems, to help find better ways to manage these issues with medications and physical activity.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 15, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $358,298 |
| NIH project number | 1P01HL169168-01A1 |
| Project ID | NIH-11015434 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults with hypertension and thoracic aortopathy, particularly those considering exercise as part of their treatment plan.
✕Less likely to help
Patients without hypertension or those who do not have thoracic aortopathy may not benefit from this research.
What this research studies
This research investigates the impact of hypertension and exercise on thoracic aortopathy, a condition affecting the aorta. It aims to clarify how different anti-hypertensive medications and exercise levels can influence the health of the aorta in patients with this condition. By studying various mouse models, the research will analyze the genetic and biomechanical factors that contribute to aortic diseases, providing insights into effective treatment strategies. The goal is to establish a clearer understanding of the relationship between blood pressure management, exercise, and aortic health.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment guidelines for patients with thoracic aortopathy, enhancing their cardiovascular health.
How similar studies have gone: Previous studies have shown varying success in understanding the effects of hypertension and exercise on aortic health, but this research aims to provide a more comprehensive and systematic approach.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Humphrey, Jay D. — Yale University
- Study coordinator: Humphrey, Jay D.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.