Understanding how hydrogen sulfide affects heart function
Official title: Regulation of CSE-Derived Hydrogen Sulfide in the Heart
Funded at Emory University · NIH-11049100 · Data updated 2026-11-12
This study is looking at how a natural molecule called hydrogen sulfide can help protect heart cells during stressful situations like heart attacks, and it aims to find new ways to improve heart health for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $472,188 |
| NIH project number | 5R01HL164806-03 |
| Project ID | NIH-11049100 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with heart conditions, particularly those experiencing heart failure or acute myocardial ischemia.
✕Less likely to help
Patients without any cardiovascular issues or those who are not experiencing heart-related stress may not benefit from this research.
What this research studies
This research investigates the role of hydrogen sulfide (H2S), a naturally occurring molecule in the body, in protecting heart cells during stress conditions like heart attacks. The study focuses on how H2S is produced by specific enzymes and how its production is regulated, particularly through a protein called AMP-activated protein kinase (AMPK). By exploring these mechanisms, the research aims to identify how H2S can help heart cells adapt to stress and potentially improve heart health. Patients may benefit from insights gained about new therapeutic strategies for heart conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance heart protection during critical conditions like heart failure.
How similar studies have gone: Previous studies have shown promising results regarding the protective effects of hydrogen sulfide in heart conditions, indicating that this research builds on established findings.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Calvert, John Winter — Emory University
- Study coordinator: Calvert, John Winter
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.