Understanding how hydrogen sulfide affects heart function
Regulation of CSE-Derived Hydrogen Sulfide in the Heart
['FUNDING_R01'] · EMORY UNIVERSITY · NIH-11049100
This study is looking at how a natural molecule called hydrogen sulfide can help protect heart cells during stressful situations like heart attacks, and it aims to find new ways to improve heart health for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-11049100 on ClinicalTrials.gov |
What this research studies
This research investigates the role of hydrogen sulfide (H2S), a naturally occurring molecule in the body, in protecting heart cells during stress conditions like heart attacks. The study focuses on how H2S is produced by specific enzymes and how its production is regulated, particularly through a protein called AMP-activated protein kinase (AMPK). By exploring these mechanisms, the research aims to identify how H2S can help heart cells adapt to stress and potentially improve heart health. Patients may benefit from insights gained about new therapeutic strategies for heart conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with heart conditions, particularly those experiencing heart failure or acute myocardial ischemia.
Not a fit: Patients without any cardiovascular issues or those who are not experiencing heart-related stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance heart protection during critical conditions like heart failure.
How similar studies have performed: Previous studies have shown promising results regarding the protective effects of hydrogen sulfide in heart conditions, indicating that this research builds on established findings.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CALVERT, JOHN WINTER — EMORY UNIVERSITY
- Study coordinator: CALVERT, JOHN WINTER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.