Understanding how hydrogen sulfide affects blood vessel remodeling
CSE regulation of vascular remodeling
This study is looking at how a specific enzyme helps produce a gas called hydrogen sulfide, which is important for keeping your blood vessels healthy, especially during times when they aren't getting enough blood; the findings could help improve treatments for heart and blood vessel issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ Hsc Shreveport NIH-funded |
| Lab location | 1 site (Shreveport, United States) |
| Project ID | NIH-10630127 on NIH RePORTER |
What this research studies
This research investigates the role of cystathionine g-lyase (CSE) in the synthesis and metabolism of hydrogen sulfide, which is crucial for cardiovascular health. By using advanced mouse models and analytical chemistry techniques, the study aims to uncover how CSE influences blood vessel responses during ischemic conditions, such as arteriogenesis and angiogenesis. The research will also explore the interactions between hydrogen sulfide and nitric oxide in vascular diseases, focusing on the molecular mechanisms that regulate these processes. Patients may benefit from insights gained about how to improve blood vessel function and health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiovascular diseases or conditions that affect blood vessel function.
Not a fit: Patients with non-cardiovascular related health issues may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing blood vessel health and treating cardiovascular diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of hydrogen sulfide in cardiovascular health, indicating that this approach has potential for significant findings.
Where this research is happening
Shreveport, United States
- Louisiana State Univ Hsc Shreveport — Shreveport, United States (Active)
Researchers
- Principal investigator: Kevil, Christopher G — Louisiana State Univ Hsc Shreveport
- Study coordinator: Kevil, Christopher G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.