Understanding how hydrogen peroxide signals in cells
Decoding Hydrogen Peroxide Signaling at Cellular Membranes
['FUNDING_OTHER'] · BOSTON CHILDREN'S HOSPITAL · NIH-11093317
This study is looking at how hydrogen peroxide helps cells communicate and react to changes in their environment, which could be important for understanding how our immune system works and how cells move around, especially for anyone interested in how our bodies handle stress and stay balanced.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11093317 on ClinicalTrials.gov |
What this research studies
This research investigates how hydrogen peroxide (H2O2) functions as a signaling molecule in eukaryotic cells, influencing various cellular processes such as immune responses and cell migration. By examining the role of H2O2 in cell membrane signaling, the study aims to uncover the mechanisms that allow cells to respond to environmental changes effectively. The research will focus on the interaction between H2O2 and specific proteins, particularly those with redox-sensitive thiol switches, to understand how these interactions regulate cellular functions. This could lead to insights into how cells maintain homeostasis and respond to stress.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to cellular signaling dysfunction, including certain types of cancer or immune disorders.
Not a fit: Patients with conditions unrelated to cellular signaling or those who do not have any known issues with hydrogen peroxide signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases where cellular signaling is disrupted, such as cancer.
How similar studies have performed: Previous research has shown promising results in understanding the role of reactive oxygen species in cellular signaling, indicating that this approach has potential for success.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: THIAGARAJAH, JAY — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: THIAGARAJAH, JAY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers