Understanding how hydrogen peroxide affects cell signaling and enzyme function
Redox Regulation of Cysteine-Dependent Peroxidases and Signal Transduction Pathways
This study is looking at how hydrogen peroxide works in our bodies and how it helps certain enzymes, called peroxiredoxins, manage it, which could lead to better understanding of health issues like cancer and infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-10766795 on NIH RePORTER |
What this research studies
This research investigates the role of hydrogen peroxide as a signaling molecule in the body, particularly how it influences various cellular processes and pathways. The study focuses on a group of enzymes called peroxiredoxins, which help manage hydrogen peroxide levels and are crucial for cell signaling. By examining the mechanisms and regulation of these enzymes, the research aims to uncover new insights into their functions in health and disease, including cancer and infectious diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to oxidative stress, such as certain cancers or chronic infections.
Not a fit: Patients with conditions unrelated to oxidative stress or those not affected by hydrogen peroxide signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases where hydrogen peroxide signaling is disrupted, such as cancer and infections.
How similar studies have performed: Previous research has shown promising results in understanding the role of peroxiredoxins in cellular processes, indicating that this approach has potential for significant advancements.
Where this research is happening
Winston-Salem, United States
- Wake Forest University Health Sciences — Winston-Salem, United States (Active)
Researchers
- Principal investigator: Poole, Leslie B — Wake Forest University Health Sciences
- Study coordinator: Poole, Leslie B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.