Understanding how hybrid cancer cells spread in colorectal cancer
Mechanisms of Neoplastic Hybrid Cell Dissemination in Colorectal Cancer
This study is looking at how special hybrid cancer cells, made from a mix of tumor and immune cells, move into the bloodstream and help spread colorectal cancer, with the goal of finding new ways to track and treat this disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10923917 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which certain hybrid cancer cells, formed from the fusion of tumor and immune cells, enter the bloodstream and contribute to the spread of colorectal cancer. The team aims to identify specific genetic pathways, particularly focusing on the RUNX1 transcription factor, that enhance the migratory and invasive capabilities of these hybrid cells. By analyzing the gene expression of these cells, the research seeks to uncover how they differ from traditional circulating tumor cells, which could lead to improved monitoring and treatment strategies for metastatic disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with colorectal cancer, particularly those with metastatic disease.
Not a fit: Patients with early-stage colorectal cancer or those without any evidence of metastatic disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new methods for detecting and targeting metastatic colorectal cancer, potentially improving patient outcomes.
How similar studies have performed: While the specific focus on hybrid cancer cells is relatively novel, previous research has shown success in understanding the mechanisms of cancer cell dissemination and metastasis.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Anderson, Ashley Nicole — Oregon Health & Science University
- Study coordinator: Anderson, Ashley Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.