Understanding how hyaluronan affects ovarian health and aging
Official title: Elucidating the role of the hyaluronan matrices on the establishment of ovarian reserve and aging
Funded at Magee-Women's Res Inst and Foundation · NIH-11136692 · Data updated 2026-11-12
This study looks at how a natural substance in the body called hyaluronan affects the health of ovaries as women get older, focusing on how it impacts fertility and the overall environment of the ovaries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Magee-Women's Res Inst and Foundation NIH-funded |
| Lab location | 1 site (Pittsburgh, UNITED STATES) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $232,308 |
| NIH project number | 1R56HD111646-01A1 |
| Project ID | NIH-11136692 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women over 21 years old who are interested in understanding ovarian health and aging.
✕Less likely to help
Patients who are pre-menopausal or have no concerns regarding ovarian health may not receive direct benefits from this research.
What this research studies
This research investigates the role of hyaluronan, a substance found in the body, in the health of ovaries and how it changes as women age. The study focuses on how the ovarian environment, including the extracellular matrix, influences the number and health of ovarian follicles, which are crucial for fertility. By examining the differences between high and low molecular weight hyaluronan, the research aims to uncover how these changes contribute to reproductive aging and inflammation in the ovaries.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preserving ovarian function and fertility in aging women.
How similar studies have gone: Previous research has shown promising results in understanding the role of the extracellular matrix in reproductive health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Magee-Women's Res Inst and Foundation
Pittsburgh, United States Active
Researchers
- Principal investigator: Brieno-Enriquez, Miguel Angel — Magee-Women's Res Inst and Foundation
- Study coordinator: Brieno-Enriquez, Miguel Angel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.