Understanding how Huntington's disease progresses differently in patients
Huntington's Disease: Learning from Extremes
This study is looking at how Huntington's disease progresses at different speeds in people who start showing symptoms at different ages, and it aims to find out what biological and genetic factors might affect this, so we can develop better treatments for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10445001 on NIH RePORTER |
What this research studies
This research investigates the varying progression rates of Huntington's disease, a genetic neurodegenerative disorder. By examining patients with different ages of onset, the study aims to identify biological and genetic factors that influence how quickly the disease advances. The approach includes analyzing brain imaging and genetic data to uncover insights that could lead to more effective treatments. Patients with early and late onset of the disease will be compared to understand the underlying mechanisms of progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Huntington's disease, particularly those with varying ages of onset.
Not a fit: Patients with other neurodegenerative disorders or those without a confirmed diagnosis of Huntington's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies tailored to the specific progression patterns of Huntington's disease.
How similar studies have performed: Previous research has shown that understanding genetic and biological factors can lead to breakthroughs in treatment for neurodegenerative diseases, suggesting this approach has potential for success.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Rosas, Herminia Diana — Massachusetts General Hospital
- Study coordinator: Rosas, Herminia Diana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.