Understanding how human stem cells mature into nerve cells
Official title: Cell Intrinsic and Extrinsic Factors Driving Maturation in Human PSC-derived Neurons
Funded at Sloan-Kettering Inst Can Research · NIH-10890861 · Data updated 2026-11-12
This study is looking at how human stem cells grow into important brain cells, which could help improve treatments for neurological conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $635,667 |
| NIH project number | 5R01NS128087-02 |
| Project ID | NIH-10890861 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with neurological disorders or conditions that could be modeled using stem cell-derived neurons.
✕Less likely to help
Patients with conditions unrelated to neurological function or those who are not candidates for stem cell therapies may not receive benefit from this research.
What this research studies
This research investigates the factors that influence the maturation of human stem cells into nerve cells and glial cells, which are crucial for brain function. By using advanced 3D cell culture techniques, the team aims to replicate the natural development process of these cells more accurately. The study will explore both intrinsic cellular mechanisms and the effects of the surrounding environment on cell maturation. Patients may benefit from insights gained that could improve treatments for neurological conditions.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for neurological diseases by enhancing the maturity and functionality of stem cell-derived neurons.
How similar studies have gone: Previous research has shown promise in using stem cells for disease modeling, but this specific approach to enhancing maturation in a 3D culture is relatively novel.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Studer, Lorenz P. — Sloan-Kettering Inst Can Research
- Study coordinator: Studer, Lorenz P.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.