Understanding how human stem cells grow and develop during early embryonic stages
Measuring and modeling the dynamics of patterning in human stem cells
This study is looking at how certain cells in early human embryos help shape the spine and muscles, using special lab techniques to understand how these cells decide to grow or change into different types of cells, which could help us learn more about human development and related health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard University NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-11099211 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the elongation of the anterior-posterior axis in human embryos, focusing on progenitor cells in the tailbud that contribute to the spinal cord and musculoskeletal system. By utilizing advanced in vitro organoid systems, live imaging, and pluripotent stem cell lines, the researchers aim to uncover how morphogen signals influence cell fate decisions between self-renewal and differentiation. The study will explore the signaling pathways and cellular behaviors that enable stable growth and elongation in developing embryos, providing insights into human development and related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to embryonic development or genetic disorders affecting growth.
Not a fit: Patients with fully developed conditions unrelated to embryonic development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of human embryonic development and the potential for new treatments for developmental disorders.
How similar studies have performed: Previous research has shown success in understanding similar developmental processes in model organisms, suggesting potential for breakthroughs in human studies.
Where this research is happening
Cambridge, United States
- Harvard University — Cambridge, United States (Active)
Researchers
- Principal investigator: Ramanathan, Sharad — Harvard University
- Study coordinator: Ramanathan, Sharad
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.