Understanding how human stem cells develop into complex tissues
Measuring and modeling the dynamics ofpatterning in human stem cells
['FUNDING_R01'] · HARVARD UNIVERSITY · NIH-10890895
This study is exploring how human stem cells decide what type of tissue to become during development, especially in the tail area of embryos, to better understand both normal growth and developmental diseases, using special lab models to get clearer results.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD UNIVERSITY (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-10890895 on ClinicalTrials.gov |
What this research studies
This research investigates how human stem cells sense signals and make decisions to develop into various tissue types during normal development and in developmental diseases. By focusing on the axial elongation of the human embryo, the study aims to uncover the mechanisms that drive this process and how progenitor cells in the tailbud maintain their population while differentiating into specialized cells. The research utilizes advanced organoid systems to model these processes in vitro, addressing challenges related to variability in traditional models.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with developmental disorders or conditions related to tissue formation.
Not a fit: Patients with fully developed tissues or those not affected by developmental diseases may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in regenerative medicine and developmental biology, improving our understanding of tissue formation and potential treatments for developmental disorders.
How similar studies have performed: Other research has shown success in using organoid systems to model developmental processes, indicating that this approach has potential for significant findings.
Where this research is happening
CAMBRIDGE, UNITED STATES
- HARVARD UNIVERSITY — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAMANATHAN, SHARAD — HARVARD UNIVERSITY
- Study coordinator: RAMANATHAN, SHARAD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.