Understanding how human retroviruses assemble and spread in the body
Analysis of human retrovirus particle assembly sites
This study is looking at how viruses like HIV-1 and HTLV-1 spread in the mouth and how they move between cells, which can help us find better ways to stop these viruses from passing from mothers to their babies.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11158553 on NIH RePORTER |
What this research studies
This research investigates how human retroviruses, such as HIV-1 and HTLV-1, assemble and spread through mucosal surfaces, particularly focusing on the oral cavity. By using advanced imaging techniques and molecular virology, the study aims to uncover the mechanisms behind cell-to-cell transmission of these viruses. The goal is to better understand how viral particles are formed and how they move within cells, which is crucial for developing strategies to prevent transmission, especially from mother to child.
Who could benefit from this research
Good fit: Ideal candidates for this research include infants and young children who may be at risk of acquiring HIV or HTLV through maternal transmission.
Not a fit: Patients who are adults or those who are not at risk for HIV or HTLV transmission may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for HIV and HTLV infections, particularly in vulnerable populations such as infants.
How similar studies have performed: Previous research has shown success in understanding retrovirus transmission, but this specific focus on assembly sites and cell-to-cell transmission is relatively novel.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Willkomm, Nora — University of Minnesota
- Study coordinator: Willkomm, Nora
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.