Understanding how human proteins influence antibiotic resistance in Acinetobacter bacteria
Identifying host human products responsible for natural transformation of resistance traits in Acinetobacter spp
['FUNDING_OTHER'] · CALIFORNIA STATE UNIVERSITY FULLERTON · NIH-10875399
This study looks at how a protein in our blood, called human serum albumin, might help a tough germ called Acinetobacter baumannii become even more resistant to antibiotics, which is important for figuring out how to fight antibiotic resistance.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CALIFORNIA STATE UNIVERSITY FULLERTON (nih funded) |
| Locations | 1 site (FULLERTON, UNITED STATES) |
| Trial ID | NIH-10875399 on ClinicalTrials.gov |
What this research studies
This research investigates how human serum albumin (HSA) affects the ability of Acinetobacter baumannii, a significant antibiotic-resistant pathogen, to acquire resistance traits. By examining the interaction between HSA and bacterial surface proteins, the study aims to uncover the mechanisms that enhance the bacteria's natural transformation process. The research employs laboratory techniques to analyze gene expression changes in response to HSA, focusing on the regulatory role of specific bacterial proteins. This work is crucial for understanding how human factors contribute to the growing problem of antibiotic resistance.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with infections caused by Acinetobacter baumannii or are at risk of such infections.
Not a fit: Patients with infections caused by other types of bacteria or those who do not have antibiotic-resistant infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for combating antibiotic-resistant infections caused by Acinetobacter baumannii.
How similar studies have performed: While the specific approach of this research is novel, previous studies have shown success in understanding bacterial resistance mechanisms through host-pathogen interactions.
Where this research is happening
FULLERTON, UNITED STATES
- CALIFORNIA STATE UNIVERSITY FULLERTON — FULLERTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAMIREZ, MARIA SOLEDAD — CALIFORNIA STATE UNIVERSITY FULLERTON
- Study coordinator: RAMIREZ, MARIA SOLEDAD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acinetobacter Infections