Understanding how human muscle stem cells develop and regenerate
Regulators of Development and Quiescence in the Human Muscle Stem Cell Lineage
This study is looking at how muscle stem cells work in people, which are important for helping muscles heal and grow, and it aims to find out how these cells can be used to improve muscle repair in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10684711 on NIH RePORTER |
What this research studies
This research investigates the origins and characteristics of muscle stem cells in humans, which are crucial for muscle regeneration. By utilizing advanced techniques to differentiate stem cells into muscle fibers in the lab, the study aims to uncover the differences between dormant and active muscle stem cells. The research combines laboratory experiments with studies in mice to explore how these cells function and their potential for therapeutic applications. This could lead to new insights into muscle repair and regeneration in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with muscle degeneration or injury, as well as those interested in stem cell therapies.
Not a fit: Patients with non-muscle related conditions or those who do not have regenerative muscle issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of muscle regeneration and lead to improved treatments for muscle-related conditions.
How similar studies have performed: Other research has shown promise in using stem cell therapies for muscle regeneration, indicating that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Pourquie, Olivier — Brigham and Women's Hospital
- Study coordinator: Pourquie, Olivier
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.