Understanding how human microglia affect brain development in health and autism
The Impact of hiPSC-Derived Microglia in Human Brain Development in Health and Disease
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-10894696
This study is looking at how special brain cells called microglia help build connections in the brain during early development, especially in kids with Autism Spectrum Disorders, to find new ways to improve treatments for these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10894696 on ClinicalTrials.gov |
What this research studies
This research investigates the role of human microglia, a type of brain cell, in forming neural networks during early brain development, particularly in the context of Autism Spectrum Disorders (ASD). The study aims to explore how genetic, environmental, and epigenetic factors influence microglial behavior and their impact on neuronal development. By examining these interactions, the research seeks to uncover potential therapeutic targets that could lead to improved treatments for neurological disorders, including ASD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Autism Spectrum Disorders or those at high risk for developing ASD.
Not a fit: Patients with neurological conditions unrelated to Autism Spectrum Disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve outcomes for individuals with Autism Spectrum Disorders.
How similar studies have performed: Previous research has shown promise in understanding the role of microglia in brain development, suggesting that this approach could yield valuable insights.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MUOTRI, ALYSSON R. — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: MUOTRI, ALYSSON R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autism Spectrum Disorder patient, Autistic Disorder