Understanding how human genetics has evolved and its impact on health.
Evolutionary Human Genomics: Demography, Natural Selection, and Transcriptional Regulation
This study is looking at how our genes have changed over time and how those changes might affect our health, so we can learn more about the genetic factors that influence diseases and help patients in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cold Spring Harbor Laboratory NIH-funded |
| Lab location | 1 site (Cold Spring Harbor, United States) |
| Project ID | NIH-11042813 on NIH RePORTER |
What this research studies
This research investigates the evolutionary forces that have shaped human genome sequences and their implications for health. By utilizing advanced statistical techniques, artificial intelligence, and population genetics, the project aims to uncover the significance of specific genomic sequences. The research focuses on reconstructing evolutionary histories, assessing the impact of human mutations, and exploring how transcriptional regulation has evolved in mammals. Patients may benefit from insights gained about genetic factors influencing health and disease.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic conditions or those interested in the genetic basis of health and disease.
Not a fit: Patients with no genetic predisposition to the conditions being studied may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic factors that influence health and disease, potentially guiding personalized medicine.
How similar studies have performed: Previous research in evolutionary genomics has shown promise in uncovering genetic insights that can inform health outcomes, suggesting that this approach may yield valuable results.
Where this research is happening
Cold Spring Harbor, United States
- Cold Spring Harbor Laboratory — Cold Spring Harbor, United States (Active)
Researchers
- Principal investigator: Siepel, Adam Charles — Cold Spring Harbor Laboratory
- Study coordinator: Siepel, Adam Charles
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.