Understanding how human genetic differences affect our health
Function and fitness consequences of human genetic variation
This work aims to uncover how variations in our DNA influence our bodies and overall well-being, using information from diverse human populations.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11116848 on NIH RePORTER |
What this research studies
Our bodies are unique because of small differences in our DNA, and this project explores how these genetic variations impact our cells and health. We are developing new computer tools to look closely at genetic information, gene activity, and health traits from many people. By studying a wide range of human populations, we hope to get a clearer picture of how our genes change over time and contribute to our individual characteristics. This understanding could help us learn more about why certain health conditions affect people differently.
Who could benefit from this research
Good fit: This foundational work does not directly involve patient recruitment for a clinical trial, but future studies building on this knowledge may seek individuals with specific genetic profiles or conditions.
Not a fit: Patients seeking immediate treatment or direct medical intervention for a specific condition would not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could provide a deeper understanding of how genetic variations contribute to health and disease, potentially leading to new ways to identify disease risks or develop personalized treatments in the future.
How similar studies have performed: While the specific computational methods are novel, the broader approach of linking genetic variation to health outcomes has been a successful area of research, with many studies contributing to our understanding of human biology.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Mccoy, Rajiv Champion — Johns Hopkins University
- Study coordinator: Mccoy, Rajiv Champion
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.