Understanding how human genes function through advanced genetic techniques
Official title: Multi-omic phenotyping of human transcriptional regulators
Funded at Jackson Laboratory · NIH-10927399 · Data updated 2026-11-12
This study is exploring how our genes work by using special tools to turn off specific genes and see how cells behave over time, which will help us understand more about gene functions and how they relate to health and disease.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project start | September 11, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $553,390 |
| NIH project number | 5U01HG013175-02 |
| Project ID | NIH-10927399 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic conditions or those interested in the genetic basis of diseases.
✕Less likely to help
Patients without genetic conditions or those not interested in genetic research may not benefit from this research.
What this research studies
This research investigates the functions of human genes by using advanced genetic techniques such as CRISPR to create targeted gene knockouts and knockdowns. By applying these techniques, researchers will profile the molecular characteristics of cells over time, using both bulk and single-cell RNA sequencing. The goal is to catalog the functions of every human gene, particularly focusing on transcription factors that play a crucial role in regulating cell behavior. This comprehensive approach aims to provide a deeper understanding of gene function and its implications for health and disease.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in understanding genetic diseases and developing targeted therapies.
How similar studies have gone: Other research has shown success with similar genetic perturbation approaches, indicating a promising avenue for understanding gene function.
Where this research is happening
-
Jackson Laboratory
Bar Harbor, United States Active
Researchers
- Principal investigator: White, Brian S — Jackson Laboratory
- Study coordinator: White, Brian S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.