Understanding how human genes function through advanced genetic techniques
Multi-omic phenotyping of human transcriptional regulators
['FUNDING_U01'] · JACKSON LABORATORY · NIH-10927399
This study is exploring how our genes work by using special tools to turn off specific genes and see how cells behave over time, which will help us understand more about gene functions and how they relate to health and disease.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JACKSON LABORATORY (nih funded) |
| Locations | 1 site (BAR HARBOR, UNITED STATES) |
| Trial ID | NIH-10927399 on ClinicalTrials.gov |
What this research studies
This research investigates the functions of human genes by using advanced genetic techniques such as CRISPR to create targeted gene knockouts and knockdowns. By applying these techniques, researchers will profile the molecular characteristics of cells over time, using both bulk and single-cell RNA sequencing. The goal is to catalog the functions of every human gene, particularly focusing on transcription factors that play a crucial role in regulating cell behavior. This comprehensive approach aims to provide a deeper understanding of gene function and its implications for health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or those interested in the genetic basis of diseases.
Not a fit: Patients without genetic conditions or those not interested in genetic research may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in understanding genetic diseases and developing targeted therapies.
How similar studies have performed: Other research has shown success with similar genetic perturbation approaches, indicating a promising avenue for understanding gene function.
Where this research is happening
BAR HARBOR, UNITED STATES
- JACKSON LABORATORY — BAR HARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WHITE, BRIAN S — JACKSON LABORATORY
- Study coordinator: WHITE, BRIAN S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.