Understanding how human genes affect cholesterol
High-throughput investigation of human genetic variants affecting cholesterol uptake and efflux
This research aims to discover new genetic factors that influence cholesterol levels, which could lead to better ways to prevent and treat heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11112416 on NIH RePORTER |
What this research studies
Heart disease is a major health concern, and differences in our genes play a big role in cholesterol levels. We are using advanced lab techniques, including CRISPR gene editing and analyzing large databases of human genetic information, to find new genes that affect how our bodies handle cholesterol. By understanding these genetic differences, we hope to uncover new ways to help people manage their cholesterol and reduce their risk of heart disease.
Who could benefit from this research
Good fit: Patients with high cholesterol or a family history of coronary artery disease are the ultimate beneficiaries of this foundational genetic understanding.
Not a fit: Patients whose cholesterol levels are not primarily influenced by the genetic pathways being studied may not directly benefit from these specific findings.
Why it matters
Potential benefit: If successful, this work could lead to new treatments and prevention strategies for coronary artery disease by identifying novel genetic targets.
How similar studies have performed: This project builds upon an established approach combining advanced genetic screening with human data analysis, while also pioneering novel refinements to this pipeline.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Sherwood, Richard I — Brigham and Women's Hospital
- Study coordinator: Sherwood, Richard I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.