Understanding how human enzymes process drugs and chemicals
Official title: Functional Roles of Human Cytochrome P450 Enzymes
Funded at Vanderbilt University · NIH-10759986 · Data updated 2026-11-12
This study is looking at special enzymes in our bodies that help break down medicines and other chemicals, with the goal of understanding how they affect the way drugs work and their safety, which could help people dealing with conditions like cancer and hormone-related issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | September 10, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $465,922 |
| NIH project number | 1R35GM151905-01 |
| Project ID | NIH-10759986 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are taking medications that may interact with cytochrome P450 enzymes or those with conditions affected by these enzymes.
✕Less likely to help
Patients who are not on any medications or do not have conditions related to drug metabolism may not receive direct benefits from this research.
What this research studies
This research investigates the roles of cytochrome P450 enzymes, which are crucial for the metabolism of a wide range of chemicals, including drugs and carcinogens. By exploring the functions of these enzymes, the research aims to improve our understanding of drug interactions and their implications for diseases such as cancer and endocrine disorders. The study employs advanced techniques in organic synthesis and molecular biology to uncover the physiological roles of various P450 enzymes and their interactions with other proteins. Patients may benefit from insights gained into how these enzymes affect drug efficacy and safety.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective drug therapies for patients.
How similar studies have gone: Previous research has shown significant advancements in understanding cytochrome P450 enzymes, indicating a strong potential for success in this area.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Guengerich, F Peter — Vanderbilt University
- Study coordinator: Guengerich, F Peter
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.