Understanding how human embryos develop and what affects their growth
Deciphering Principles of Human Embryonic Patterning in Development and Disease
This study is looking at how human embryos develop in their early stages by using special stem cells to create a 3D model, helping scientists understand how cells form different layers and how factors like nutrition affect this process.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10471048 on NIH RePORTER |
What this research studies
This research investigates the early stages of human embryonic development, focusing on how cells differentiate and form the three major germ layers. Using human pluripotent stem cells and advanced bioengineering techniques, the project aims to create a 3D model of human epiblast development in a controlled laboratory setting. By employing cutting-edge genetics, imaging, and computational analyses, researchers will explore the molecular and cellular events that guide embryonic patterning and how these processes are influenced by cellular metabolism and nutrient availability.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in developmental biology or those affected by conditions related to embryonic development.
Not a fit: Patients with fully developed conditions unrelated to embryonic development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of developmental disorders and better strategies for regenerative medicine.
How similar studies have performed: Other research has shown promise in using stem cell models to study embryonic development, indicating that this approach has potential for success.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Sozen, Berna — Yale University
- Study coordinator: Sozen, Berna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.