Understanding how human centromeres are formed and maintained during cell division
Supplement to Promote Diversity: Mechanisms of epigenetic assembly, maintenance and propagation of human centromeres
This study is looking at how a special part of our DNA helps keep our chromosomes in order during cell division, which is important for everyone, especially for understanding conditions that affect how our cells work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11075457 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the assembly and maintenance of human centromeres, which are crucial for the accurate distribution of chromosomes during cell division. The team focuses on the role of a specific histone variant, CENP-A, in the epigenetic regulation of centromeres. By utilizing advanced techniques like ChIP-sequencing, the researchers aim to create a comprehensive map of human centromeres and their epigenomic landscape. This work could provide insights into various conditions related to cell division and chromosome stability.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions related to chromosomal abnormalities, such as certain cancers or genetic disorders.
Not a fit: Patients with conditions unrelated to chromosomal stability or those not experiencing issues with cell division may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for diseases related to chromosome missegregation, such as cancer and genetic disorders.
How similar studies have performed: Previous research has shown success in understanding centromere biology and its implications for chromosome stability, indicating that this approach builds on established findings.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Nechemia-Arbely, Yael — University of Pittsburgh at Pittsburgh
- Study coordinator: Nechemia-Arbely, Yael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.