Understanding how human cells repair their DNA
Molecular Mechanisms of Human Homologous Recombination
['FUNDING_OTHER'] · CORNELL UNIVERSITY · NIH-11124779
This project explores how our cells naturally fix damaged DNA, a process crucial for preventing diseases like cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CORNELL UNIVERSITY (nih funded) |
| Locations | 1 site (ITHACA, UNITED STATES) |
| Trial ID | NIH-11124779 on ClinicalTrials.gov |
What this research studies
Our bodies are constantly exposed to things that can damage our DNA, and this damage can lead to serious health issues like cancer. Fortunately, our cells have natural repair systems, such as homologous recombination, that help fix these dangerous breaks. This project aims to understand the detailed steps of how human cells choose the correct DNA template to repair these breaks, focusing on the many proteins that control this complex process. By learning more about how these repair systems work in humans, we hope to find new ways to protect our cells and prevent disease.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future clinical applications may target individuals with specific cancers or those at high risk due to DNA repair deficiencies.
Not a fit: Patients looking for immediate new treatments will not directly benefit from this foundational laboratory work.
Why it matters
Potential benefit: Successfully understanding these repair mechanisms could lead to new strategies for preventing and treating cancers by improving how we protect our DNA.
How similar studies have performed: While DNA repair mechanisms are well-studied in simpler organisms, this project focuses on the less understood, specific processes within human cells.
Where this research is happening
ITHACA, UNITED STATES
- CORNELL UNIVERSITY — ITHACA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CRICKARD, JOHN BROOKS — CORNELL UNIVERSITY
- Study coordinator: CRICKARD, JOHN BROOKS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, DNA Injury