Understanding how human cells repair DNA damage
Mapping the DNA damage response in human cells with high-resolution functional genomics
This study is looking at how our cells fix damage to their DNA, which happens a lot, and it aims to understand how these repair systems work together, especially when one of them doesn't work right; this could help improve treatments for conditions like cancer that are linked to DNA repair problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project ID | NIH-10896164 on NIH RePORTER |
What this research studies
This research investigates the complex mechanisms that human cells use to detect and repair DNA damage, which occurs frequently in our cells. By utilizing advanced CRISPR techniques and high-resolution genomic analysis, the study aims to uncover how these repair processes work together and adapt when one pathway fails. This knowledge is crucial for understanding diseases like cancer, particularly those associated with DNA repair deficiencies, and could lead to improved therapeutic strategies. Patients may benefit from insights gained through this research that could enhance treatment options for DNA repair-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers that involve DNA repair deficiencies or related genetic disorders.
Not a fit: Patients with cancers that do not involve DNA repair mechanisms may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for cancers associated with DNA repair deficiencies.
How similar studies have performed: Other research has shown promising results using CRISPR and functional genomics to study DNA repair mechanisms, indicating that this approach has potential for success.
Where this research is happening
Princeton, UNITED STATES
- Princeton University — Princeton, United States (Active)
Researchers
- Principal investigator: Adamson, Brittany S. — Princeton University
- Study coordinator: Adamson, Brittany S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.