Understanding how human cells repair DNA damage
Molecular Mechanisms of Human Homologous Recombination
This study looks at how our cells fix serious DNA damage, which can lead to cancer, by using healthy DNA as a guide, and it aims to understand how this process works in humans compared to simpler organisms like yeast.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-10862887 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms behind how human cells repair dangerous DNA damage known as double strand breaks. It focuses on a process called homologous recombination, where cells use undamaged DNA sequences to restore lost genetic information. By studying the proteins involved in this repair process, the research aims to uncover how these mechanisms function in humans compared to simpler organisms like yeast. This could provide insights into the genetic stability and integrity of human cells, particularly in relation to cancer development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of cancer or those who have experienced genetic mutations that affect DNA repair.
Not a fit: Patients with no known genetic predisposition to DNA repair issues or those without a history of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for cancer prevention and treatment by enhancing our understanding of DNA repair mechanisms.
How similar studies have performed: Previous research has shown success in understanding DNA repair mechanisms in simpler organisms, but this specific focus on human homologous recombination is relatively novel.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Crickard, John Brooks — Cornell University
- Study coordinator: Crickard, John Brooks
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.