Understanding how human cells repair damaged chromosomes
Mechanisms of chromosome damage repair in human cells
['FUNDING_R01'] · COLORADO STATE UNIVERSITY · NIH-10873953
This study is looking at how our cells fix damaged DNA, especially in a way that could help make cancer treatments work better for people with certain types of tumors.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLORADO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (FORT COLLINS, UNITED STATES) |
| Trial ID | NIH-10873953 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which human cells repair damaged chromosomes, particularly focusing on a process called homologous recombination (HR). The study aims to identify which stages of this repair process are most vulnerable to inhibition, which could enhance the effectiveness of cancer treatments. By exploring the roles of specific proteins involved in HR, the research seeks to develop new therapeutic strategies that could improve outcomes for patients with HR-proficient tumors. The ultimate goal is to create more effective cancer therapies that target these repair pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with HR-proficient tumors who are undergoing treatment for cancer.
Not a fit: Patients with HR-deficient tumors or those not currently receiving cancer treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments that prevent tumor recurrence and improve patient survival rates.
How similar studies have performed: Other research has shown promise in targeting DNA repair mechanisms in cancer cells, indicating that this approach could lead to significant advancements in cancer therapy.
Where this research is happening
FORT COLLINS, UNITED STATES
- COLORADO STATE UNIVERSITY — FORT COLLINS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WIESE, CLAUDIA — COLORADO STATE UNIVERSITY
- Study coordinator: WIESE, CLAUDIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Treatment