Understanding How Human Cells Cope with Stress in Their Energy Factories
Mechanistic Elucidation of Mitochondrial Stress Response in Human Cells
This research explores how our cells' powerhouses, called mitochondria, respond to stress to keep us healthy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project ID | NIH-11143209 on NIH RePORTER |
What this research studies
Our cells have tiny power plants called mitochondria that are vital for energy. When these power plants get stressed, our cells have ways to cope and fix them. This project aims to understand these coping mechanisms, specifically a pathway called the integrated stress response (ISR). By learning more about how cells manage mitochondrial stress, we hope to find new ways to help people with conditions related to mitochondrial problems.
Who could benefit from this research
Good fit: Patients with disorders linked to mitochondrial dysfunction might eventually benefit from treatments developed from this fundamental understanding.
Not a fit: This foundational research is not directly testing treatments in patients, so immediate direct benefit is not expected.
Why it matters
Potential benefit: If successful, this work could identify new targets for medicines to treat diseases caused by mitochondrial dysfunction.
How similar studies have performed: This project builds upon recent discoveries by the research team, suggesting a novel approach to understanding mitochondrial stress responses.
Where this research is happening
Farmington, United States
- University of Connecticut Sch of Med/dnt — Farmington, United States (Active)
Researchers
- Principal investigator: Guo, Xiaoyan — University of Connecticut Sch of Med/dnt
- Study coordinator: Guo, Xiaoyan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.