Understanding how human brain cells develop into glial cells
Molecular Drivers of Human Gliogenesis
This study is looking at how certain brain cells, called glial cells, are formed from other cells in the human brain, which is important for keeping our brain healthy, and it aims to help people understand more about brain development and disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11083057 on NIH RePORTER |
What this research studies
This research investigates the processes that lead to the formation of glial cells in the human brain, which are essential for supporting neurons. By using human-derived brain organoids, the study aims to identify the specific progenitor cells where the transition from neuron to glia occurs and the intrinsic mechanisms that drive this change. The research focuses on understanding how these processes differ in humans compared to other species, which could have implications for neurodevelopmental disorders. Patients may benefit from insights gained into the cellular origins of glial cells and their roles in brain health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental disorders or those interested in the cellular mechanisms of brain development.
Not a fit: Patients with conditions unrelated to neurodevelopment or those who do not have a vested interest in brain cell development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating neurodevelopmental disorders by targeting the mechanisms that control glial cell formation.
How similar studies have performed: Previous research has shown success in understanding glial cell development in other species, but this study aims to explore human-specific mechanisms, making it a novel approach.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Sloan, Steven a — Emory University
- Study coordinator: Sloan, Steven a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.