Understanding how human brain activity affects gene expression and plasticity
Official title: Discovering human divergent activity-regulated elements using comparative, computational, and functional approaches
Funded at University of California, San Francisco · NIH-10929471 · Data updated 2026-11-12
This study is looking at how new experiences can change the way our brains work and how our genes respond, especially to help us understand what makes our brains unique compared to other animals, which could give us clues about how we learn and why some people might be more at risk for certain brain disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $816,779 |
| NIH project number | 5R01MH134981-02 |
| Project ID | NIH-10929471 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation would include individuals with neurodevelopmental disorders or those interested in cognitive development.
✕Less likely to help
Patients with stable neurological conditions that do not involve developmental changes may not benefit from this research.
What this research studies
This research investigates how new experiences influence brain activity and gene expression, particularly focusing on the unique aspects of human brain plasticity compared to other species. By examining the genetic changes that support this enhanced plasticity, the study aims to identify specific genomic elements that respond to brain activity. Using both experimental and computational methods, researchers will analyze these elements to better understand their role in cognitive capabilities and potential vulnerabilities to neurodevelopmental disorders. This work could lead to insights into how our brains adapt and change throughout development.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain development and lead to new strategies for addressing neurodevelopmental disorders.
How similar studies have gone: Previous research has shown promise in understanding brain plasticity through genetic analysis, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Pollen, Alexander a — University of California, San Francisco
- Study coordinator: Pollen, Alexander a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.