Understanding how human antibodies protect against picornaviruses
Official title: Protective human antibodies for picornaviruses
Funded at Vanderbilt University Medical Center · NIH-10863660 · Data updated 2026-11-12
This study is looking at how well vaccines help our bodies fight off certain viruses that can cause everything from colds to more serious illnesses, and if you’re willing to share a blood sample, you can help us learn more about how these vaccines work!
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | August 20, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $5,421,688 |
| NIH project number | 1U19AI181979-01 |
| Project ID | NIH-10863660 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include children under 11 years old who have received vaccinations against picornaviruses.
✕Less likely to help
Patients who are older than 11 years or those who have not been vaccinated against picornaviruses may not benefit from this research.
What this research studies
This research investigates the immune response to picornaviruses, which can cause illnesses ranging from mild colds to severe conditions like meningitis. The team will analyze how antibodies generated from vaccines can protect against these viruses, focusing on four specific types that affect the respiratory and gastrointestinal systems. By studying the antibody responses in vaccinated individuals, the research aims to develop adaptable vaccine strategies for future picornavirus outbreaks. Patients may contribute by providing blood samples to help understand these immune responses better.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccines and treatments for picornavirus-related diseases, enhancing protection for children and vulnerable populations.
How similar studies have gone: Previous research has shown success in developing vaccines against picornaviruses, indicating that this approach has potential for further advancements.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Vogt, Matthew R — Vanderbilt University Medical Center
- Study coordinator: Vogt, Matthew R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.